“The quality, not the longevity, of one's life is what is important.”

Who wants to live forever?

Most people think they want to live forever, until they consider the possibility that living forever would just mean centuries of debilitating pain and decrepitude.  But what if aging is really just a collection of curable conditions?  If you thought about living forever as extending your health-span rather than your life-span, does that change most people’s answer to, yes please!

Scientists have made two huge breakthroughs in recent years. First, they have been able to determine the biological age of organisms using a process known as the Horvath clock, which looks at the biomarkers of aging to determine real age rather than chronological age. Second, using a process based on the recently discovered Yamanaka factors, they have been able to reverse the biological age of cells almost back to their blank stem cell state, stopping the reversal while they still have their identity as a specific cell.  This is a long way of saying, we’ve turned back the aging clock. So what does that mean for you? And what are the ethics of life extension, on a personal and collective level?

Episode Features

Aubrey De Gray

Chief Science Officer

Aubrey De Gray is a biomedical gerontologist and Chief Science Officer at SENS Research Foundation and VP of New Technology Discovery at AgeX Therapeutics, Inc.

James Peyer, PhD

Founder and CEO

James Peyer holds a doctorate in stem cell biology from the University of Texas Southwestern Medical Center and is the CEO of Cambrian Biopharma which develops therapeutics targeting the biology of aging.

David Sinclair, PhD

Co-Director/ Paul F. Glenn Center for Biology of Aging Research

David Sinclair is a biologist and Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for Biology of Aging Research at Harvard Medical School.

Matthias Steger


Matthias Steger is a biotech entrepreneur and CEO of Rejuveron Life Sciences AG, which develops drugs and technologies with the potential to prolong the human lifespan.

Your host

Your host

Pietro Boselli, PhD, is a mechanical engineer and teacher, specialising in Mathematical Modelling and Analysis.

He began modelling when he was discovered by Giorgi Armani at age 6, and since then has been featured by brands and magazines including GQ, Equinox Fitness, Emporio Armani EA7, Attitude, Vouge Hommes, Abercrombie & Fitch, and has been shot by photographers including Bruce Weber, Giampalo Sgura, and Ollie Ali.

Pietro’s interests in fitness led to his innovative YouTube strength training channel being viewed millions of times, and the launch of his own fitness-oriented fashion line Pietra Design.

A Facebook post by one his University of London engineering students went viral in 2015 and led to his being dubbed “the world’s sexiest math teacher”, to which Pietro replies, “I model the fluid thermodynamics of wet steam flow”.

Rational mind is the continuation of that philosophy: using the global platform he has been gifted to help millions of curious people discover more about how their world works, and how to think about it.

For RATIONAL MIND, Pietro chose to collaborate with ATOMIC ENTERTAINMENT, the Emmy-nominated creators & executive producers of BRAIN GAMES, BRAINCHILD and the WHO SMARTED? podcast. Pietro And Atomic's founders, Jerry Kolber and Adam Davis, all share the belief that critical thinking, science and enabling discovery are the keys to making the world a better place.

Critical Thinking

Learn what the future really holds and how to think critically about the truth

Download our introduction to critical thinking and learn the framework for how to think in a way that can lead to progress and cooperation.